
	TEST SCHEDULES
	Cellular Flow Cytometry Immunohistochemistry Sub Cellular Classic Cytogenetics Digital Image Analysis Sub Chromosomal Molecular Cytogenetics FISH Molecular Molecular Genetics- PCR

Myelodysplasia Tests

Cytogenetic and molecular cytogenetic endpoints in suspected myelodysplasia are helpful in determining underlying genetic abnormalities that may contribute to the hematologic condition.



	TESTS BY DISEASE
	Bladder Cancer Breast Cancer Coagulation Disorders Colorectal Cancer Genetic Syndrome Hematologic Disorders Immunodeficiency Infertility Leukemia Lymphoma Lung Cancer Myelodysplasia Myeloma Prenatal Diagnosis Prostate Cancer Sarcoma

**Tests By Disease**
ref#	Disease	Test Type	Test Name	CPT code	Includes	Description
80	Myeloproliferative disorders	Chromosome Analysis: Cytogenetics	Bone Marrow Chromosome Analysis	88237 (1), 88264* (1), 88280(2), 88291 (1)	Cell Culture, Chromosome Analysis, & Interpretation	Chromosome analysis of bone marrow aspirate to decipher the etiology of hematologic disease. Diseases include myelodysplasias, acute leukemias, chronic leukemias, lymphomas, and myeloproliferative disorders.
13	Myeloproliferative disorders	FISH	BCR / ABL t(9;22) -- with 9q34 (ASS) --	88271 (3), 88275 (1), 88291 (1)	Probe hybridization, Analysis, & Interpretation	BCR/ABL t(9;22) Found in 90-95% of all CML, FISH is the recommended tool used for diagnosis of CML or the initial Philidelphia chromosome detection.The BCR/ABL translocation is found in 90-95% of all chronic myelogenous leukemias (CML) patients and 30% of acute lymphocytic leukemias (ALL) cases. The presence of the Philadelphia chromosome can be used to diagnose CML and to assess the prognosis. It may also be used to predict disease remission and relapse and to monitor therapeutic response to Gleevac. The addition of 9q34/ASS to the probe cocktail ensures that all variant BCR/ABL rearrangements are detected. Deletions in 9q34 may adversely impact identification of a t(9;22).
78	Myeloproliferative disorders	PCR	JAK2 V617F Activating Mututation	83890 (1), 83901 (2), 83894 (1), 83892 (1) ,83912 (1)	Extraction, Multiplex, Restriction Digest, Gel Electrophoresis, & Interpretation	Polycythemia vera and other myeloproliferative disorders harbor activating mutations in JAK2. Testing is performed on peripheral blood or bone marrow in patients with chronic myeloproliferative disorders, such as polycythemia vera.
14	Myeloproliferative disorders	RT-PCR (QPCR)	BCR / ABL t(9;22)	83890 (1), 83898 (1), 83896 (1), 83902 (1), 83912 (1)	Extraction, Amplification/Primer, Nucleic Acid Probes, Reverse Transcription, & Interpretation	BCR/ABL Gene Rearrangement t(9;22) quantitative real time RT-PCR(QPCR). The BCR/ABL translocation is found in 90-95% of all chronic myelogenous leukemias (CML) patients and 30% of acute lymphocytic leukemias (ALL) cases. The presence of the Philadelphia chromosome can be used to diagnose CML and ALL and to assess the prognosis. It may also be used to predict disease remission and relapse and to monitor therapeutic response to Gleevec.